RIAM D 1 : Review Document EPSRC
نویسنده
چکیده
This report is intended to be the conduit by which information is passed from the PhD student to the RA (who started 6 months after). It contains a review of the current literature on the Accessible Web and the Mobile Web. The report discusses approaches and guidelines on achieving and evaluating Web Accessibility. It also explains characteristics of the Mobile Web and discusses related accessibility issues. Based on the knowledge gained from this report, further investigation on the interoperability between the Accessible Web and the Mobile Web can be conducted.
منابع مشابه
The adaptor molecule RIAM integrates signaling events critical for integrin-mediated control of immune function and cancer progression.
Lymphocyte activation requires adhesion to antigen-presenting cells. This is a critical event linking innate and adaptive immunity. Lymphocyte adhesion is accomplished through LFA-1, which must be activated by a process referred to as inside-out integrin signaling. Among the few signaling molecules that have been implicated in inside-out integrin activation in hematopoietic cells are the small ...
متن کاملRap1 and its effector RIAM are required for lymphocyte trafficking.
Regulation of integrins is critical for lymphocyte adhesion to endothelium and trafficking through secondary lymphoid organs. Inside-out signaling to integrins is mediated by the small GTPase Rap1. Two effectors of Rap1 regulate integrins, RapL and Rap1 interacting adaptor molecule (RIAM). Using mice conditionally deficient in both Rap1a and Rap1b and mice null for RIAM, we show that the Rap1/R...
متن کاملFocal adhesion disassembly is regulated by a RIAM to MEK-1 pathway.
Cell migration and invasion require regulated turnover of integrin-dependent adhesion complexes. Rap1-GTP-interacting adaptor molecule (RIAM) is an adaptor protein that mediates talin recruitment to the cell membrane, and whose depletion leads to defective melanoma cell migration and invasion. In this study, we investigated the potential involvement of RIAM in focal adhesion (FA) dynamics. RIAM...
متن کاملThree Proteins Regulating Integrin Function – Filamin, 14-3-3 and RIAM
Takala, Heikki Three proteins regulating integrin function – filamin, 14-3-3 and RIAM Jyväskylä: University of Jyväskylä, 2011, 78 p. (Jyväskylä Studies in Biological and Environmental Science ISSN 1456-9701; 232) ISBN 978-951-39-4523-7 (nid.) ISBN 978-951-39-4524-4 (PDF) Yhteenveto: Kolme integriinin toimintaa säätelevää proteiinia – filamiini, 14-3-3 ja RIAM Diss. Integrins are transmembrane ...
متن کاملMechanisms and consequences of agonist-induced talin recruitment to platelet integrin αIIbβ3
Platelet aggregation requires agonist-induced alphaIIbbeta3 activation, a process mediated by Rap1 and talin. To study mechanisms, we engineered alphaIIbbeta3 Chinese hamster ovary (CHO) cells to conditionally express talin and protease-activated receptor (PAR) thrombin receptors. Human PAR1 or murine PAR4 stimulation activates alphaIIbbeta3, which was measured with antibody PAC-1, indicating c...
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